Li Y, Zhang T, Sun D (2009) New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Goetz MP, Toft DO, Ames MM, Erichman C (2003) The Hsp90 chaperone complex as a novel target for cancer therapy. Curr Opin Oncol 15:419–424Ĭhiosis G, Vilenchik M, Kim J, Solit D (2004) Hsp90: the vulnerable chaperone. Neckers L, Ivy SP (2003) Heat shock protein 90. The role of hsp90 in cancer, tumor selectivity of Hsp90 inhibitors and the current status of Hsp90 inhibitors are discussed in the present review. All this has led to a rapid pace discovery of Hsp90 clients as well as chemical inhibitors of Hsp90. Moreover Hsp90 inhibitors selectively kill cancer cells compared to normal cells and cancer cells have greater dependence on Hsp90 for the maintenance of intracellular protein homeostasis. Inhibition of Hsp90 can affect multiple oncogenic pathways simultaneously. Dependence of these proteins on Hsp90 makes this chaperone an appealing target for cancer therapeutics. Almost all these proteins depend upon the molecular chaperone Hsp90 for their proper folding, stability and function and thus are a part of the Hsp90 clientele. These include key players in malignant transformation like protein kinases, transcription factors, steroid hormone receptors, cell cycle regulators, signal transduction proteins and regulators of apoptosis. With increasing understanding of the molecular basis of carcinogenesis, its progression and metastasis, the cancer therapy has shifted from empirical approaches to targeting specific molecules that regulate the complex network of signalling pathways for cell survival and proliferation.
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With a huge selection of high-quality premade templates and great options such as text-to-speech, custom cartoon characters, and a big graphic assets library, this animation platform allows you to create professional-looking animations fast and easily. Price: Free Version | $19/mo | $149/one-time purchaseĪnireel by Wondershare is another option to consider for creating animations. While Canva is not designed for complex animations, it is the perfect option to create your content for marketing purposes fast and easily. They offer dozens of templates that you can try and create animated social media posts, stories, banners, and more. Price: Free Version | Canva Pro – $12,99/moĬanva is continuously expanding its services and now, you can make animations on their platform. Want to learn more about Adobe Character Animator? Canva Animator Plus, you’ll find plenty of useful tutorials to help you start, and pre-made puppets for free download or for sale, so you don’t really need drawing skills, as well. They will lip-sync your voice with ease and accuracy.Ĭharacter Animator is a great animation software for beginners. The animated character is called a puppet and they will copy your every movement and facial expression. You will only need a camera and a mic, and the software will do the rest. The possibilities are endless – you can make explainer videos, lectures, social media ads, video presentations, youtube videos, and even your own animation series with a character. Price: Character Animator Starter – Free | Creative Cloud – $54.99/moĪ character animation software by Adobe, designed to make literally everyone able to create animation.
I’ve known Larry Young, Marty Ellen and Rodger Collins for close to 15 years, and the way they’ve evolved Dr Pepper Snapple Group in the past 10 years is amazing.” Repole adds: “They made us a national brand in January. “Our products are really incremental to them as well as to dozens of independent distributors around the country.” “Dr Pepper Snapple is a leading distributor in the country, and they gave us an important route to market,” Manning says. It’s also a win-win for DPS because BODYARMOR is the first successful sports drink in its portfolio, filling an important void, Repole notes. “BODYARMOR has been a winning addition to our allied brand lineup, enabling us to build our presence in the growing sports drink category with a great-tasting and differentiated product,” said Rodger Collins, DPS president of packaged beverages, in a statement at the time of the added investment. To date, DPS has invested $26 million in BODYARMOR, including an additional $6 million investment in April that raised the company’s ownership position from 11.7 to 15.5 percent, making it the second largest equity holder. Repole credits the company’s partnership with Plano, Texas-based Dr Pepper Snapple Group (DPS) for taking BODYARMOR to the next level by providing “distribution muscle” and carrying the brand in 34 states, enabling national distribution. … Once we start getting into those bigger outlets, if the timing is right, we’ll see our sales really skyrocket.” We’re selling the hard cases now - the cases in convenience stores, the mom and pops - and we’re starting to get grocery accounts. Manning adds: “We continue to grow the business, and we’ve just scratched the surface. We’re up 150 percent year-to-date, but if you look at sales in the last four weeks, we’re up 200 percent,” he says. “We’re having a nice year and our business is up triple-digits. The brand is gaining momentum in the category, notes Frank Manning, the company’s vice president of sales in the East. “But no company has been able to compete with them head-on as a sports drink. “Gatorade is an iconic brand that’s been around for 50 years, while Powerade has been around for 30, and I give them all the credit,” he says. Sports Beverages.” Repole says there’s room for innovation in the growing sports drink category. 3 sports drink brand behind Purchase, N.Y.-based PepsiCo Inc.’s Gatorade and Atlanta-based The Coca-Cola Co.’s Powerade and their respective SKUs, IRI data shows.Īlthough Gatorade and Powerade comprise 90 percent of the volume in the sports drink industry, according to New York-based Beverage Marketing Corporation’s November 2015 report titled “U.S. With 38.5 million units sold for the year ending in June, a 176 percent increase year-to-year, BODYARMOR is now the No. supermarkets, drug stores, mass merchandisers, gas and convenience stores, military commissaries, and select club and dollar retail chains in the 52 weeks ending June 12, according to Chicago-based Information Resources Inc. Body Armor is owned by Keurig Dr Pepper, which acquired the company in 2018 for $420 million.In the non-aseptic sports drink category, BODYARMOR generated $62.6 million in sales, and a triple-digit 148 percent increase year-to-date, in U.S. The drink is designed to help athletes recover from workouts and improve their performance. Conclusionīody Armor is a sports drink that was created by Lance Armstrong and his business partner, Mike Repole. The company is headquartered in Purchase, New York. BodyArmor is a sports drink company that was founded in 2011. Is Bodyarmor Owned by Coke?īodyArmor is not owned by Coke. Collins saw a need for a healthier alternative to traditional sports drinks, which are often high in sugar and calories.īodyArmor is made with all-natural ingredients and has no artificial sweeteners or colors. BodyArmor has been around since 2011 and was created by Lance Collins, who also created Fuze Beverage and NOS Energy Drink. Who is Bodyarmor Owned By?īodyArmor is a sports drink company that is owned by Keurig Dr. So, if you’re ever feeling thirsty during a game of pick-up hoops, remember: Kobe drinks BodyArmor. The company has been growing rapidly in recent years, thanks in part to endorsements from big names like Bryant and LeBron James. That means that Kobe has made a cool $20 million from his investment, which he first made back in 2014.īodyArmor is now valued at $2 billion after being purchased by Coca-Cola earlier this year. The former NBA star turned entrepreneur has sold his 10% stake in the company for $200 million, according to a report by ESPN. Kobe Bryant’s investment in sports drink company BodyArmor is paying off. How Much Did Kobe Bryant Make from Bodyarmor? His stake in the company is now worth an estimated $200 million. So does Kobe still own BodyArmor? Yes, he does. OnyX is a multifunction utility that you can use to verify the startup disk and the structure of its system files, to run miscellaneous maintenance and cleaning tasks, to configure parameters in the Finder, Dock, Safari, and some of Apple's applications, to delete caches, to remove certain problematic folders and files, to rebuild various databases and indexes, and more. Cleaner for 10.7 5 onyx mac how to#Ĭleaning caches usually makes the Mac slower for a while until the caches can be built back up. This series of utilities for eqach system is unfortunately named, it is serious software, unlike ll these new 'cleaners' - which do too much and which you do not need, and which are made for new users, Try one of Northern Software's versions, take your time with its amazing number of features. So cache cleaning is only there to resolve problems with the cache, not to guarantee that you will "speed things up."įor a normally functioning Mac, Onyx probably won't make any difference in speed. Using Onyx can be a good idea if you are enough of a power user that you know why each setting is there, you know what it is you would specifically like to change about your Mac, and you know which specific Onyx settings will do that and which ones will not. › California Society For Healthcare Engineering Inc Csheįrequently Asked Questions What is the best free mac cleaning software?.OnyX is one of the best free MAC cleaner software that can be used to clean your MAC. Here you can perform a number of tasks that can help you clean and optimize your MAC. This helps you perform a number of tasks that are not easily accessible. Cleaning caches usually makes the Mac slower for a while until the caches can be built back up. It can also be used to Secure Clean MAC hard drive. So cache cleaning is only there to resolve problems with the cache, not to guarantee that you will 'speed things up.' For a normally functioning Mac, Onyx probably wont make any difference in speed. Macaroni is one of the best Mac cleaner software programs, and it will not only remove all the undesirable programs and files, but will also make sure that your iOS system is constantly updated, and it will speed up all other operations. What is the best mac computer cleaner?īest Mac Cleaner Software in 2021 CleanMyMac X CCleaner Disk Doctor Daisy Disk Drive Genius AppCleaner Disk Inventory X AVG Cleaner for Mac OnyX What is the best free mac cleaner app?ĬCleaner has arguably been the top choice for free optimization software for both Mac and PC users for the last decade. Things are mildly trickier in the modelresources folder, so use View > Arrange By > Date Added in the Finder's menu to bring the most recently added items (the folder containing your newly imported Live Photo's video) to the top of the view. Finding the still part in the Masters folder is relatively simple because subfolders there organise photos by year, month and date taken. The other hurdle, also in step 6, is locating the parts of that Live Photo after importing it into your Mac's photo library. This may seem nonsensical given the portrait Lock screen, but any other way will require you to rotate your still in Preview to ensure it and your video are the same way up on your phone this saves you some experimentation. First, when taking a Live Photo in step 6, hold your iPhone in landscape orientation, with its Home button on the right. There are two stumbling blocks to be aware of. Note that the crossfade and enlargement from a Live Photo's still part to its video is baked into iOS and can't be suppressed, but perhaps you've realised this already with Live Photos made using your iPhone's camera. This opens up all sorts of opportunities to turn hand-drawn or computer-generated animations into Lock screen wallpapers, or you may just want to convert an animated GIF of amusing animal antics for when you need a pick-me-up just press your phone's screen and try not to burst out laughing if you're somewhere that would be inappropriate! Obstacles to watch out for (If you prefer, you can use another app that can export QuickTime movies in Keynote's place.) It turns out that it's possible using nothing more than Keynote, Photos and a shared photo album published to iCloud. The ability to use a Live Photo as the Lock screen wallpaper on an iPhone 6S or iPhone 6S Plus is ripe for fun, yet Apple provides no way to use an existing video in this way. Mugen Souls Z is currently only available on PS3. When the original Mugen Souls was brought over NIS America chopped out an interactive bath mini-game, much to the chagrin of fans. I'm unsure what the "sensitive content" that's being removed might be in this case. 9999 levels of maniacal mishaps and ethereal adventures await Sylma, her crew, and hordes of Shampurus as Mugen Souls Z hits Western shores in 2014!" Sylma is out to stop an ancient threat to her world that has recently awakened. Taking place immediately after the first game, you take control of the goddess Sylma, who meets Chou-Chou before the end of the first game’s events. "Our favorite Undisputed God of the Universe, Chou-Chou, returns with her crew for a brand-new story revolving around the zodiac. Here's how NIS America summarises Mugen Souls Z: NIS America says it will be editing "certain aspects" of the game "due to the sensitive nature of some content." The Compile Heart-developed game features a free-roaming battle map, turn-based combat, and a level cap of 9999. Prime 1 Studio Collectors Group Kingdom Hearts FanClub The Legend of. It has the complete Org.NIS America will be bringing Mugen Souls Z to North America and Europe some time in 2014, the company has announced. Final Fantasy VII Everything Nintendo Funko POPS Buy, Sell, Trad. I also packed in there every Kindgom Hearts stages i could find I also edited Lonesomeazn 's Kh Screenpack added much more slots and converted it from mugen 1.0 to 1.1 Just wanted to share my kingdom hearts mugen collection over here since it was very difficult for me to find alll the good versions of each character and so i leave it here for you guys Kingdom Hearts Mugen Full Game by Lonesomeazn, Edited by Dave Rattlz (1.1) Kingdom Hearts Mugen Full Game by Lonesomeazn Olympic Coliseum & WonderLand by Tetsuo9999 || Hollow Bastion by Kamui_Kanjal || The Chamber of Awakening By Kanbei Kingdom Hearts Stages by Phoenix Gaming! || Chain Of Memories Boss Stage by kymugen || Guard Armor: Shayneral || Stealth Sneak: ultraboard101 || Kurt Zisa: Shayneral Screw Diver: Shayneral || Wyvern: Shayneral Green Requiem: jointhemasters || Black Ballade: ShayneralĬreeper Plant: Shayneral || Defender: Allen || Gargoyle: Shayneral || Neoshadow: Ultraboard101 || Aqua Tank: Shayneral If the stage is uploaded in the Downloads section page, just remember that it will also automatically create a topic in this forum due to any updates from the stages section. KH Sephiroth: Valecent || Red Nocturne: Shayneral || Blue Rhapsody: Shayneral || Yellow Opera: Shayneral || Post any Mugen Stages you would like to share or chat about. Soldier: Ultraboard101 || Large Body: hackymcsackman / Shayneral || Bandit: Shayneral || KH Sephiroth: 1st: Valecent / Xatoku / 2nd: Kronos Vexen: Xatoku / Ultraboard101 / Valecent / Lonesomeazn Marluxia: Xatoku / Unknown / Ultraboard101 / Marluxia Valacent and Ultraboard101 || Xemnas: LordDMX / Ultraboard101 Master Xehanort: 1st: JTD95 / 2nd: Ultraboard101(Old Chaser) || Ansem: akimooto / d_kuane2323 She is the 14th Member of Organization 13. She was first (and only) introduced in 'Kingdom Hearts 358/2 Days' for the Nintendo DS. KH1 Cloud: 1st: hyuga / 2nd: DARK!! || KH2 Cloud: Ninja_Naruto Xion is a character from the series Kingdom Hearts. Goofy: 1st: Felix2011 / Asakumo / 2nd: Ultraboard101 / 3rd: model OCX King M ickey: 1st: LordDMX / 2nd: XkingofmastersX / 3rd: Shayneral || Hooded King Mickey : Superfluous || Timeless River KH Mickey : Shayneralĭonald: 1st: Ultraboard101 / 2nd: model OCX Xion: 1st: Freddery II / 2nd: Ultraboard101 Namine: 1st: ChosenByTheKeyblade / 2nd: Freddery II Riku: 1st: HackyMcSackMan / 2nd: kadeem / Unknownkid / Ultraboard101 / itachi-kun / 3rd: Model OCXīlack Robed Riku: 1st: Xatoku / HackyMcSackMan / 2nd: Hilton Garden / 3rd: S.Nara || Dark Riku: 1st: Valacent / 2nd: Xatoku / valacent || Ansem Riku: 1st: Shayneral / 2nd: Lonesomeazn Riku And Sora Gay Hentai Adult Archive Comments 5 Kingdom Hearts Sora Gay. Roxas: 1st: Retrocognition / 2nd: Lonesomeazn / 3rd: S.Naraĭuel Wield Roxas: 1st: Lonesomeazn / 2nd: ChosenByTheKeyblade / Ultraboard101 / Unknown /īlack Robed Roxas: 1st: Nomad / Blank / 2nd: Unknown / 3rd: maps4890 || Skating Roxas: Shayneral Sora Muscle appealing Yaoi Photo Roxas and Sora Kingdom hearts fanart Kingdom. Lion Sora: Xatoku || Atlantica Sora: Shayneral || Cyber Valor Sora: maps4890 Valor Form Sora: Lonesomeazn || Wisdom Form Sora: 1st: Gotenks07 / Blank / 2nd: Valacent || Master Form Sora: 1st: Ultraboard101 / Cloud kh1 / Lonesomeazn / 2nd: NostalgiaX / lil inu x || Anti-Form Sora: Shadow02143 Sora KH2: 1st: Omegabros6 / SinShadow91 / Itachi-Kun / Ichisennen, ZXtales23 / 2nd: Asch815 / Ichisennen, Putz, ZXtales23 / Ichisennen, ZXtales23 / 3th: HackyMcSackMan / 4th: Lone Star Cal / 5th: Shiruzato/Mythos Sora KH1: Lonesomeazn / Princefluffy09 / Bane84 If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. 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You will use the power drill to notch areas for the leads and power wires to run. Once the dry run is successful, add a layer of thinset to the top of the cement board and place the heating system in place as a final lay down. This mat will be attached to the cement board before you add the wiring. This is a rubber “peg board” that allows you to wrap the wiring around as needed. If, on the other hand, you are using a wired set you need to ensure that the wires are long enough and molded to fit around the space. If you are using a mat or pad style heating element, you need to place it down as a “dry run.” This means laying the entire thing out to ensure it fits the space, around your fixtures or appliances and matches the manufacturer’s layout plan. Because we cannot see into every one of your homes to find out where you are starting, the first assumption we will make is that your old flooring has been removed down to the subfloor. This basic installation guide will make a few assumptions. You will need to seal the edges between the cement boards and mesh tape is the ideal component. Your subfloor and heating system will determine which, if any, of these items you need for a base and protection on the underside of your floor. Cement board/underlayment/moisture barrier.Whether you use a mat, straight wiring, or a rolled pad, this is the main factor of the entire project. You will need to finish the tile flooring and grout is one of the last steps to your project. As a mortar, thinset is easy to work with, conducts heat well and sets up durable and sturdy. Ceramic tile is preferred, but porcelain will work, too. The finishing layer is the one that will be visible and walked on. In general, though, you will need the following materials. There are a few different options, including wire, mat or pad. As with the tools, your materials list will vary depending on the type of heating system you decide to go with. While it isn’t the most popular option, radiant heat-approved carpet can hold heat for a long time and it doesn’t expand or contract like some options can.Īside from the tools, you will also need the materials. Like LVP and laminate, engineered hardwood planks are a DIY friendly radiant heating option. Like tile, stone heats quickly and retains heat, it is not always easy to install, though. LVP and laminate offer even heating and most brands offer ranges that are DIY radiant capable. Tied for second place are luxury vinyl and laminate planks. Tiles floors (and the focus of this article) are the best option for radiant flooring because of the durability and even heating. Here is the generally accepted order of flooring materials. Top Flooring Options Over Radiant Heatingįrom best to worst, there is an order that works well (or not) with radiant heating. Frequently Asked Questions about Heated Tile Floors.How to Install Heated Floors Under Tile.Materials Needed for Heated Flooring Installs.Tools Needed to Install Heated Tile Floors.Top Flooring Options Over Radiant Heating. For most of them, I use the copyright date on the box or instruction sheet. I've also made a stab at the issue date of the kit. Most of the kits listed are injection molded plastic. If you see any errors or can provide confirmation on those kits that I've indicated confirmation is needed or have additions for this page, please email me. If there's a green dot ( ) in front of the kit name, then the link includes not only the boxart, but also full sized scans of the instructions, decals, and maybe some additional stuff. Here, I've organized the models by subject and scale and I've added links to photographs of the kit boxes for those that I have or that people have sent me. I've also relied heavily on now out of print The Collector's Value Guide for Scale Model Plastic Kits by John W. A copy of this list used to be found at, but it's not there anymore (and don't ask me where it is, because I don't know). I used Greg Bollendonk's Spacecraft models list as the starting point for this compilation. Ninfinger Productions: Spacecraft models Spacecraft and X-Plane Models Elementary students at 15 schools in Richmond, San Pablo and Oakland are reaping benefits because of ZSharp, a nonprofit supported by corporate and foundation grants and individual donors which works in partnership with schools to bring in music instruction.Īccording to the California Department of Education, reading and math scores double over the first five years zSharp is at a given school. Younger kids also respond to music training. Over those same two school years, McClymond’s dropout rate dropped almost in half, from 35.3 percent to 18.8 percent.Įven more telling, no such head-turning changes were seen at similar schools in Oakland Unified that did not receive music training. Other schools that 51Oakland visited saw their graduation rates rise, in McClymond’s case an even more impressive 15 percentage points from 2011-12 to 2013-14. In those same two years, Castlemont’s dropout rate fell nearly 10 percentage points.Īlthough it’s impossible to tease out exactly how many of those changes can be directly attributed to the influence of one program, a look at similar schools in the district helps. According to the state Department of Education, in just the two years 51Oakland had been at Castlemont, its graduation rate had risen to 63.9 percent for LeRoy’s class, the class of 2013-14. The teacher told Hofmann about the young talent.Īnd, perhaps even more applause-worthy, in a school where graduation rates had been languishing around 52.9 percent the school year that 51Oakland arrived on the scene, LeRoy graduated. LeRoy stuck with it, and soon he got noticed. “I started going to my music teacher’s really early, before school, to get on the drums, play my music,” LeRoy says. Then he discovered 51Oakland music classes and his place at a drum set. Hofmann talks of a Castlemont student, LeRoy Crosby, who had lost both of his parents and was at a crossroads: Stay in school or on the streets. These include McClymonds High School, which hadn’t offered music in 12 years, and Castlemont High, once home to the world-renowned Castleers choir that had played from South Africa to the White House lawn. One of those groups is 51Oakland, cofounded by Jason Hofmann and jazz club maven Yoshi Akiba in 2011, which brings music training into Oakland Unified School District’s poorest-performing schools. In the Bay Area, similar nonprofit organizations funded by grants and donations also are bringing teachers and instruments into classrooms, from Mountain View to Oakland to Richmond, and with them equally impressive upticks in attendance and graduation rates. Its success has convinced school administrators and parents alike that music training may hold a key to closing the achievement gap that persists between underserved and prosperous schoolkids in the United States. Harmony, the program at the heart of the study, serves poor communities in Los Angeles. From time immemorial, parents have been happy when children’s music lessons yielded piano keys plunked in some semblance of “Greensleeves.” So news last year of research showing that schools with graduation rates hovering around 50 percent raised those rates to 93 percent with something so simple as music lessons was just more music to their ears. |
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